[OL-Forum] Digest Number 1442

[OutdoorLighting-Forum@yahoogroups...]

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There are 3 messages in this issue.

Topics in this digest:

      1. NMHPA Winter Issue - several night sky articles
           From: "David Penasa" <dpenasa@unm...>
      2. LAN and breast cancer article
           From: susan harder <lookout@hamptons...>
      3. Cancer Research abstract
           From: kgfleming@att...


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Message: 1         
   Date: Fri, 2 Dec 2005 11:05:31 -0700
   From: "David Penasa" <dpenasa@unm...>
Subject: NMHPA Winter Issue - several night sky articles

The Winter 2005 issue of the New Mexico Heritage Preservation Alliance
(NMHPA) is out and contains several articles related to protecting dark
skies, including the following:
- article "Protecting Dark Night Skies" (reprinted by permission from Chad
Moore, NPS Night Sky Team)
- Night Sky Survey Program (outdoor lighting evaluation survey program)
- 2005 Awards (includes several awards for night sky friending lighting)
- Night Sky Program (summary of recent activities)

http://www.nmheritage.org/files/nmhpa_nwsltr_winter_05_web_version.pdf



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Message: 2         
   Date: Fri, 02 Dec 2005 16:24:41 -0600
   From: susan harder <lookout@hamptons...>
Subject: LAN and breast cancer article

Sent to me from an upstate environmentalist:

http://www.telegraphindia.com/1051202/asp/atleisure/story_5549239.asp

Susan Harder




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Message: 3         
   Date: Sat, 03 Dec 2005 00:05:14 +0000
   From: kgfleming@att...
Subject: Cancer Research abstract

Good one Susan. Here's the abstract from Cancer Research -
http://cancerres.aacrjournals.org/cgi/content/abstract/65/23/11174

[excerpt]

"These results are the first to show that the tumor growth response to exposure to light during darkness is intensity dependent and that the human nocturnal, circadian melatonin signal not only inhibits human breast cancer growth but that this effect is extinguished by short-term ocular exposure to bright, white light at night."

Wonder if this takes some of the wind out of whats-her-name at LRC - "Mice are nocturnal so the research doesn't count." This is human blood and human breast cells.

Kevin

 
----
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats 

David E. Blask, George C. Brainard, Robert T. Dauchy, ...et al, etc.

The increased breast cancer risk in female night shift workers has been postulated to result from the suppression of pineal melatonin production by exposure to light at night. Exposure of rats bearing rat hepatomas or human breast cancer xenografts to increasing intensities of white fluorescent light during each 12-hour dark phase (0-345 µW/cm2) resulted in a dose-dependent suppression of nocturnal melatonin blood levels and a stimulation of tumor growth and linoleic acid uptake/metabolism to the mitogenic molecule 13-hydroxyoctadecadienoic acid. Venous blood samples were collected from healthy, premenopausal female volunteers during either the daytime, nighttime, or nighttime following 90 minutes of ocular bright, white fluorescent light exposure at 580 µW/cm2 (i.e., 2,800 lx). Compared with tumors perfused with daytime-collected melatonin-deficient blood, human breast cancer xenografts and rat hepatomas perfused in situ, with nocturnal, physiologically melatonin-rich blood collected during the night, exhibited markedly suppressed proliferative activity and linoleic acid uptake/metabolism. Tumors perfused with melatonin-deficient blood collected following ocular exposure to light at night exhibited the daytime pattern of high tumor proliferative activity. These results are the first to show that the tumor growth response to exposure to light during darkness is intensity dependent and that the human nocturnal, circadian melatonin signal not only inhibits human breast cancer growth but that this effect is extinguished by short-term ocular exposure to bright, white light at night. These mechanistic studies are the first to provide a rational biological explanation for the increased breast cancer risk in female night shift workers. 
--

David E. Blask1, George C. Brainard2, Robert T. Dauchy1, John P. Hanifin2, Leslie K. Davidson1, Jean A. Krause1, Leonard A. Sauer1, Moises A. Rivera-Bermudez3, Margarita L. Dubocovich3, Samar A. Jasser2, Darin T. Lynch1, Mark D. Rollag4 and Frederick Zalatan1 
1 Laboratory of Chrono-Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, New York; 2 Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania; 3 Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and 4 Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 

Requests for reprints: David E. Blask, Laboratory of Chrono-Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY 13326. Phone: 607-547-3677; Fax: 607-547-3061; E-mail: david.blask@bassett....


 -------------- Original message ----------------------
From: susan harder <lookout@hamptons...>
> Sent to me from an upstate environmentalist:
> 
> http://www.telegraphindia.com/1051202/asp/atleisure/story_5549239.asp
> 
> Susan Harder


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