[Svetlo]Light and breast cancer (fwd)
Fri, 20 Apr 2001 16:21:50 +0200 (CEST)
Date: 20 Apr 2001 11:14:57 -0000
Subject: Digest Number 300
To subscribe to the DarkSky List Forum send email
From: Stephen Pauley <spauleyAcox-internet...>
Subject: Light and breast cancer
Dark sky warriors:
Below are Dr David Blask's top 15 references
linking exposure to light at night to breast cancer.
Anyone who says there is no solid evidence for this
linkage should be referred to these publications.
>Here are my top articles. Sorry it took me a while to get them to you. Hope
>all is well in Ketchum.
>Warmest personal regards,
>1. Blask,DE, Sauer, LA, Dauchy,RT, Holowachuk, EW, Ruhoff, MS and Kopff, HS.
>Melatonin inhibition of cancer growth in vivo involves suppression of tumor
>fatty acid metabolism via melatonin receptor-mediated signal transduction
>events. Cancer Res. 59:4693-4701, 1999.
>2. Dauchy, RT, Sauer, LA, Blask, DE, Vaughan, GM. Light contamination during
>the dark phase in photoperiodically controlled animal rooms: effect on tumor
>growth and metabolism in rats. Lab. Animal Sci. 47:511-518, 1997.
>3. Dauchy, RT, Blask, DE, Sauer, LA, Brainard, GC, Krause, JA. Dim light
>during darkness stimulates tumor progression by enhancing tumor fatty acid
>uptake and metabolism. Cancer Lett. 144:131-136, 1999.
>4. Hill, SM, Blask, DE. Effects of the pineal hormone melatonin on the
>proliferation and the morphological characteristics of human breast cancer
>cells. Cancer Res. 48:6121-6126, 1988.
>5. Blask, DE,Wilson, ST, Zalatan, F. Physiological melatonin inhibition of
>human breast cancer growth in vitro: evidence for a glutathione-mediated
>pathway. Cancer Res. 57:1909-1914, 1997.
>6. Blask, DE, Pelletier, DB, Hill, SM, Lemus-Wilson, A, Grosso, DS, Wilson,
>ST, Wise, ME. Pineal melatonin inhibition of tumor promotion in
>N-nitroso-N-methylurea on mammary carcinogenesis:potential involvement of
>antiestrogenic mechanisms in vivo. J. Cancer Res. Clin. Oncol. 117:526-532,
>7. Kothari, LS, Shah, PN, Mhatre, MC. Pineal ablation in varying
>photoperiods and the incidence of 9,10-dimethyl-1,2-benzanthracene induced
>mammary cancer in rats. Cancer Lett. 22:99-102, 1984.
>8. Shah, PN, Mhatre, MC, Kothari, LS. Effect of melatonin on mammary
>carcinogenesis in intact and pinealectomized rats in varying photoperiods.
>Cancer Res. 44:3403-3407, 1984.
>9. Stevens,RG. Electric power and breast cancer: a hypothesis. Am. J.
>Epidem. 125:556-561, 1987.
>10. Hahn, RA. Profound bilateral blindness and the incidence of breast
>cancer. Epidemiology 2:208-210, 1991.
>11. Feychting M, Osterland, B, Ahlbom, A. Reduced cancer incidence among the
>blind. Epidemiology 9:490-494, 1998.
>12. Pukkala, E, Verkasalo, PK, Ojamo, M, Rudanko, S-L. Visual impairment and
>cancer: a population-based cohort study in Finland. Cancer Causes and Control
>13. Verkasalo, P, Pukkala, E, Stevens,RG, Ojama M, Rudanko, S-L. Inverse
>association between breast cancer incidence and degree of visual impairment in
>Finland. Br. J. Cancer 80:1459-1460, 1999.
>14. Kliukiene, J, Tynes, T, Andersen, A. Risk of breast cancer among
>Norwegian women with visual impairment. Br. J. Cancer 84:397-399, 2001.
>15. Hansen, J. Increased breast cancer risk among women who work
>predominantly at night. Epidemiology 12:74-77, 2001.
Steve Pauley MD
"Nature bats last and owns the stadium."